According to the U.S. Census Bureau, the county has a land area of 516.33 square miles and is part of the Tallahassee Metropolitan Statistical Area. Gadsden County is in the Eastern Standard Time Zone. Its western border with Jackson County forms the boundary in this area between the Eastern Standard and Central Standard Time Zones.
Decatur County, Georgia - north
Seminole County, Georgia - north
Grady County, Georgia - northeast
Leon County, Florida - east
Liberty County, Florida - southwest
Calhoun County, Florida - southwest
Jackson County, Florida - northwest